Domain Adaptation of Digital Pathology Images using Joint Stain Color and Image Quality Constraints

Digital pathology diagnosis systems face significant domain shift problems that hinder their performance on new datasets. Existing methods for aligning digital pathology images from different domains mainly focus on stain color and overlook the potential domain shifts caused by variations in image quality. To address this issue, we propose a novel parametric model that incorporates both stain color and image quality constraints for domain adaptation of digital pathology images. We evaluate our approach on the domain adaptive mitosis detection task through extensive experiments and ablation studies, showing that our method outperforms other state-of-the-art methods.