Compensatory Brain Connection Discovery in Alzheimers Disease

Identification of the specific brain networks that are vulnerable or resilient in neurodegenerative diseases can help to better understand the disease effects and derive new connectomic imaging biomarkers. In this work, we use brain connectivity to find pairs of structural connections that are negatively correlated with each other across Alzheimer?s disease (AD) and healthy populations. Such anti-correlated brain connections can be informative for identification of compensatory neuronal pathways and the mechanism of brain networks? resilience to AD. We find significantly anti-correlated connections in a public diffusion-MRI database, and then validate the results on other databases.