Single-Cell Tracking With Compton Pet: An In Silico Feasibility Study

In vivo single-cell tracking of metastatic cancer cells, immune cells, stem cells, etc., is important for developing new therapeutic techniques. Positron Emission Tomography (PET) system is extensively used for this. The new concept of Compton PET has various advantages over conventional PET. One of the advantages is the ability to acquire singles events through scattering of inner scatterer ring. In this work, we investigated the feasibility of single-cell tracking in Compton PET system. It is a simulation based work. We used both singles and doubles events to track the unknown trajectory of the single-cell. We investigated a range of velocities and activities of single-cell. We found the benefit of using both types of events together in some ranges of velocities and activities.