Elasticity Quantification Using An Empirical Relationship Between Single Transducer-armonic Motion Imaging-Derived Displacement Versus Oscillation Frequency

Mechanical properties of tissues are diagnostically relevant. To interrogate mechanical properties via amplitude-modulated acoustic radiation force (AM-ARF)-induced displacement, single-transducer harmonic motion imaging (ST-HMI) modifies the duration of the discrete excitation pulse (DEP) to generate AM-ARF and interleaves the tracking pulses with DEPs to estimate displacement. This study uses a multi-frequency excitation pulse to generate peak-to-peak displacement (P2PD) at 100 to 1000 in steps of 100 Hz simultaneously and then, generates a slope-1 image by fitting a regression line to log (P2PD) versus frequency data. Initial feasibility was demonstrated by imaging 6 and 70 kPa inclusion in an 18 kPa background and a 4T1 breast cancer mouse tumor on Day 11 and 27 post-injection of tumor cells. There was a