Design And Fabrication Of 3D-Printed Ovarian Mold For Hubmap

The Human BioMolecular Atlas Program (HuBMAP) is a National Institutes of Health funded consortium dedicated to the mapping of all healthy cells in the human body. For human ovaries, existing sectioning tools, such as the Sadie-Riggs Tissue Slicer, have several limitations including an inability to maintain organ orientation while sectioning, inability to accommodate an adult sized ovary, and fixed slice thickness. This work aims to design, fabricate, and implement a 3D-printed mold for standardized tissue sectioning of explanted human ovaries for spatially resolved cellular and tissue analyses. The project adapts concepts from 3D-printed brain and prostate tissue mold designs to generate customized whole-organ templates.